For research use only. Not for therapeutic Use.
DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases. DB0614 degrades AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity[1].
| Catalog Number | I042901 |
| CAS Number | 2769753-47-9 |
| Synonyms | N-[3-[2-[4-[4-[5-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxypentyl]piperazin-1-yl]anilino]thieno[3,2-d]pyrimidin-7-yl]phenyl]methanesulfonamide |
| Molecular Formula | C41H42N8O7S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C41H42N8O7S2/c1-58(54,55)46-28-8-5-7-26(23-28)31-25-57-34-24-42-41(45-37(31)34)43-27-11-13-29(14-12-27)48-20-18-47(19-21-48)17-3-2-4-22-56-33-10-6-9-30-36(33)40(53)49(39(30)52)32-15-16-35(50)44-38(32)51/h5-14,23-25,32,46H,2-4,15-22H2,1H3,(H,42,43,45)(H,44,50,51) |
| InChIKey | GZRWNUKQJFXVTH-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)NC1=CC=CC(=C1)C2=CSC3=CN=C(N=C32)NC4=CC=C(C=C4)N5CCN(CC5)CCCCCOC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O |
| Reference | [1]. Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05. |
