DBCO-​C6-​acid

• CAT Number: I017166
• CAS Number: 1425485-72-8
• Molecular Formula: C₂₁H₁₉NO₃
• Molecular Weight: 333.38
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: 6-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-6-oxohexanoic acid
• InChI: InChI=1S/C21H19NO3/c23-20(11-5-6-12-21(24)25)22-15-18-9-2-1-7-16(18)13-14-17-8-3-4-10-19(17)22/h1-4,7-10H,5-6,11-12,15H2,(H,24,25)
• InChIKey: NIRLBCOFKPVQLM-UHFFFAOYSA-N
• SMILES: C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCCCC(=O)O

DBCO-C6-acid (Cat No.:I017166) is a chemical compound commonly used in bioorthogonal chemistry, especially for click chemistry applications. It contains a dibenzocyclooctyne (DBCO) group, which is highly reactive with azides in “click” reactions, enabling selective and efficient conjugation without interfering with cellular processes. The C6 refers to a six-carbon spacer that enhances the steric properties and solubility of the molecule. DBCO-C6-acid is often used for labeling biomolecules, drug delivery, and bioconjugation, offering a versatile tool in the synthesis of complex molecular structures in research and therapeutic development.

Reference

[1]. Almaliti J, et al. Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents.