DBCO-acid

• CAT Number: I017194
• CAS Number: 1353016-70-2
• Molecular Formula: C₁₉H₁₅NO₃
• Molecular Weight: 305.33
• Purity: ≥95%
• Target: ADC Linker
• Storage: -20°C
• IUPAC Name: 4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoic acid
• InChI: InChI=1S/C19H15NO3/c21-18(11-12-19(22)23)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13H2,(H,22,23)
• InChIKey: NDLOVDOICXITOK-UHFFFAOYSA-N
• SMILES: C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCC(=O)O

DBCO-acid (Cat No.: I017194) is a degradable ADC linker, which can be used to synthesize ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and the conjugate DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid is a reactant for the synthesis of advanced polyester dendrimers. DBCO-acid is a carboxylic acid derivative, which can be used as a pharmaceutical intermediate.

Reference

[1]. Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61.