DBCO-C2-SulfoNHS ester

• CAT Number: I015289
• CAS Number: 1803279-86-8
• Molecular Formula: C₂₃H₁₈N₂O₈S
• Molecular Weight: 482.46
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 1-[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid
• InChI: InChI=1S/C23H18N2O8S/c26-20(11-12-22(28)33-25-21(27)13-19(23(25)29)34(30,31)32)24-14-17-7-2-1-5-15(17)9-10-16-6-3-4-8-18(16)24/h1-8,19H,11-14H2,(H,30,31,32)
• InChIKey: WXRUVQUSPDYTKA-UHFFFAOYSA-N
• SMILES: C1C(C(=O)N(C1=O)OC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42)S(=O)(=O)O

DBCO-C2-SulfoNHS ester (Cat.No:I015289) is a chemical compound used in bioconjugation and labeling techniques. It is a sulfonated derivative of dibenzocyclooctyne (DBCO), allowing for specific and efficient conjugation to molecules containing primary amines. This reagent enables the attachment of DBCO-functionalized compounds to amine-containing biomolecules for various biomedical and research applications.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.