DBCO-CONH-S-S-NHS ester

• CAT Number: I016254
• CAS Number: 1435934-53-4
• Molecular Formula: C₂₈H₂₇N₃O₆S₂
• Molecular Weight: 565.66
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethyldisulfanyl]propanoate
• InChI: InChI=1S/C28H27N3O6S2/c32-24(29-16-18-39-38-17-15-28(36)37-31-26(34)13-14-27(31)35)11-12-25(33)30-19-22-7-2-1-5-20(22)9-10-21-6-3-4-8-23(21)30/h1-8H,11-19H2,(H,29,32)
• InChIKey: RPNGUSKTYYIUDE-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCSSCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42

DBCO-CONH-S-S-NHS ester (Cat.No:I016254) is a versatile chemical compound used in bioconjugation and labeling strategies. It contains a disulfide linker, allowing for reversible conjugation to molecules containing primary amines. This reagent enables the attachment of DBCO-functionalized compounds to amine-containing biomolecules, providing flexibility in various biomedical and research applications.

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.