DBCO-NH-(CH2)4COOH

• CAT Number: I016318
• CAS Number: 2375193-74-9
• Molecular Formula: C₂₄H₂₄N₂O₄
• Molecular Weight: 404.46
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 6-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-6-oxohexanoic acid
• InChI: InChI=1S/C24H24N2O4/c27-22(11-5-6-12-24(29)30)25-16-15-23(28)26-17-20-9-2-1-7-18(20)13-14-19-8-3-4-10-21(19)26/h1-4,7-10H,5-6,11-12,15-17H2,(H,25,27)(H,29,30)
• InChIKey: WHJBJOBCKOQKTD-UHFFFAOYSA-N
• SMILES: C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)CCCCC(=O)O

DBCO-NH-(CH2)4COOH (Cat.No:I016318) is a chemical compound used in bioconjugation and labeling techniques. It features a terminal DBCO group attached to a flexible spacer arm with a carboxylic acid group. This reagent enables specific conjugation to molecules containing primary amines and offers versatility in the design of functionalized biomolecules for various research and biomedical applications.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562