DBCO-NHCO-PEG4-NH-Boc

• CAT Number: I017130
• CAS Number: 1255942-12-1
• Molecular Formula: C₃₄H₄₅N₃O₈
• Molecular Weight: 623.74
• Purity: ≥95%
• Target: PROTAC
• IUPAC Name: tert-butyl N-[2-[2-[2-[2-[3-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate
• InChI: InChI=1S/C34H45N3O8/c1-34(2,3)45-33(40)36-17-19-42-21-23-44-25-24-43-22-20-41-18-15-31(38)35-16-14-32(39)37-26-29-10-5-4-8-27(29)12-13-28-9-6-7-11-30(28)37/h4-11H,14-26H2,1-3H3,(H,35,38)(H,36,40)
• InChIKey: YUOUOEOEOWCRQI-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)NCCC(=O)N1CC2=CC=CC=C2C#CC3=CC=CC=C31

DBCO-NHCO-PEG4-NH-Boc（Cat No.:I017130） is a linker molecule used in the synthesis of PROTACs (proteolysis-targeting chimeras). It belongs to the PEG/Alkyl/ether-based linker class. The linker contains a DBCO group, which enables bioorthogonal click chemistry reactions, facilitating the conjugation of the linker to the target protein and the attached small molecule ligand. The PEG4 segment provides flexibility, while the NHCO- and NH-Boc groups allow for cleavage of the linker under specific conditions. This cleavable ADC linker is utilized in the construction of antibody-drug conjugates (ADCs) for the targeted delivery of drugs to cancer cells.

Reference

[1]. Kuzmin A, et al. Surface functionalization using catalyst-free azide-alkyne cycloaddition.