DBCO-PEG1-NH-Boc

• CAT Number: I016056
• CAS Number: 2364591-77-3
• Molecular Formula: C₂₈H₃₃N₃O₅
• Molecular Weight: 491.58
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: tert-butyl N-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethyl]carbamate
• InChI: InChI=1S/C28H33N3O5/c1-28(2,3)36-27(34)30-17-19-35-18-16-29-25(32)14-15-26(33)31-20-23-10-5-4-8-21(23)12-13-22-9-6-7-11-24(22)31/h4-11H,14-20H2,1-3H3,(H,29,32)(H,30,34)
• InChIKey: YZCZDGHHGDLMRC-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCOCCNC(=O)CCC(=O)N1CC2=CC=CC=C2C#CC3=CC=CC=C31

DBCO-PEG1-NH-Boc is a PEG-based PROTAC linker utilized in the synthesis of PROTACs (proteolysis-targeting chimeras). This linker consists of a dibenzocyclooctyne (DBCO) moiety, a polyethylene glycol (PEG) spacer with one ethylene glycol unit and a Boc-protected amine group. The DBCO group enables bioorthogonal click chemistry reactions, allowing for the conjugation of different ligands to the linker. The PEG spacer imparts flexibility and hydrophilicity to the PROTAC molecule, while the Boc protecting group ensures stability during synthesis. This linker facilitates the formation of PROTACs, enabling targeted protein degradation through the recruitment of E3 ligases.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562