DBCO-PEG2-NH-Boc

• CAT Number: I016055
• CAS Number: 2377004-08-3
• Molecular Formula: C₃₀H₃₇N₃O₆
• Molecular Weight: 535.63
• Purity: ≥95%
• Target: PROTAC Linkers

DBCO-PEG2-NH-Boc(CAT: I016055) is a compound used in chemical synthesis and bioconjugation applications. It consists of a PEG (polyethylene glycol) linker with two ethylene glycol units (PEG2), a terminal azide group (DBCO), and a Boc-protected amine group (NH-Boc). The DBCO group can react with azide-modified molecules through a copper-free click chemistry reaction called strain-promoted azide-alkyne cycloaddition (SPAAC), enabling bioconjugation and the attachment of various molecules to the PEG linker.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562