DBCO-PEG4-DBCO

• CAT Number: I017016
• CAS Number: 2182601-68-7
• Molecular Formula: C₄₈H₅₀N₄O₈
• Molecular Weight: 810.93
• Purity: ≥95%
• Target: PROTAC

DBCO-PEG4-DBCO(CAT: I017016) is a compound that consists of two DBCO (dibenzocyclooctyne) groups connected by a polyethylene glycol (PEG) linker of four ethylene glycol units. DBCO is a reactive group that readily forms covalent bonds with azide groups through a copper-free click reaction known as strain-promoted azide-alkyne cycloaddition (SPAAC). The PEG linker provides flexibility and hydrophilicity to the molecule. DBCO-PEG4-DBCO is commonly used as a bifunctional linker in bioconjugation and drug delivery applications, enabling the attachment of molecules or drugs that contain azide groups to form stable conjugates through click chemistry.

Reference

[1]. Adam TIBBLES, et al. Engineered O-glycosylation in recombinant polypeptides via heterologous glycosylation sites. WO2019122234A1.