DBCO-PEG4-MMAF

• CAT Number: I015294
• CAS Number: 2360411-65-8
• Molecular Formula: C₆₉H₉₉N₇O₁₅
• Molecular Weight: 1266.56
• Purity: ≥95%
• Target: Drug-Linker Conjugates for ADC
• IUPAC Name: (2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[3-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoyl-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl]-3-methoxy-2-methylpropanoyl]amino]-3-phenylpropanoic acid
• InChI: InChI=1S/C69H99N7O15/c1-12-48(6)64(57(86-10)44-61(80)75-34-20-27-56(75)65(87-11)49(7)66(81)71-54(69(84)85)43-50-21-14-13-15-22-50)74(9)68(83)62(46(2)3)72-67(82)63(47(4)5)73(8)59(78)32-35-88-37-39-90-41-42-91-40-38-89-36-33-70-58(77)30-31-60(79)76-45-53-25-17-16-23-51(53)28-29-52-24-18-19-26-55(52)76/h13-19,21-26,46-49,54,56-57,62-65H,12,20,27,30-45H2,1-11H3,(H,70,77)(H,71,81)(H,72,82)(H,84,85)/t48-,49+,54-,56-,57+,62-,63-,64-,65+/m0/s1
• InChIKey: RBWQPQSLVDNXHD-KAHYCXMTSA-N
• SMILES: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N3CC4=CC=CC=C4C#CC5=CC=CC=C53

DBCO-PEG4-MMAF(CAT: I015294) is a bifunctional molecule combining a Dibenzocyclooctyne (DBCO) group, a polyethylene glycol (PEG4) linker, and monomethyl auristatin F (MMAF), a cytotoxic payload. The DBCO group enables copper-free click chemistry, facilitating site-specific conjugation with azide-functionalized molecules. The PEG4 linker provides enhanced solubility and flexibility, while MMAF, a potent tubulin polymerization inhibitor, is commonly used in antibody-drug conjugates (ADCs) for targeted cancer therapy. DBCO-PEG4-MMAF is highly significant in oncology research, where it supports the development of next-generation ADCs and other targeted drug delivery systems, providing a powerful tool for advancing cancer treatment strategies.