DBCO-PEG4-NHS ester

• CAT Number: I016066
• CAS Number: 1427004-19-0
• Molecular Formula: C₃₄H₃₉N₃O₁₀
• Molecular Weight: 649.69
• Purity: ≥95%
• Target: PROTAC Linkers

DBCO-PEG4-NHS ester (CAT: I016066) is a versatile bioconjugation reagent used for chemical modification in biotechnology. It contains an N-hydroxysuccinimide (NHS) ester for selective coupling to primary amines and a Dibenzocyclooctyne (DBCO) group for click chemistry reactions with azide-modified molecules. The PEG4 linker enhances solubility and flexibility, facilitating efficient conjugation without compromising biological activity. It is widely utilized in various applications, including protein labeling, drug delivery, and bioimaging, offering a reliable tool for site-specific and bioorthogonal conjugation strategies.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562