For research use only. Not for therapeutic Use.
DBCO-PEG5-NHS ester（Cat No.:I017129） is a linker molecule used for the synthesis of proteolysis targeting chimeras (PROTACs) and antibody-drug conjugates (ADCs). It belongs to the PEG class and Alkyl/ether class of linkers. The linker contains a cleavable DBCO moiety, which enables the attachment of the linker to a molecule of interest via a bioorthogonal click reaction. The PEG5 spacer enhances solubility and flexibility of the conjugate, while the NHS ester facilitates efficient conjugation to primary amines. The resulting conjugates can be used for targeted protein degradation or as potent anticancer agents.
| Catalog Number | I017129 |
| CAS Number | 2144395-59-3 |
| Molecular Formula | C₃₆H₄₃N₃O₁₁ |
| Purity | ≥95% |
| Target | PROTAC |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| InChI | InChI=1S/C36H43N3O11/c40-32(11-12-33(41)38-27-30-7-2-1-5-28(30)9-10-29-6-3-4-8-31(29)38)37-16-18-46-20-22-48-24-26-49-25-23-47-21-19-45-17-15-36(44)50-39-34(42)13-14-35(39)43/h1-8H,11-27H2,(H,37,40) |
| InChIKey | OYNJSALGAVUYGZ-UHFFFAOYSA-N |
| SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42 |
| Reference | [1]. Craig L. Duvall, et al. Conjugation of lipophilic albumin-binding moiety to rna for improved carrier-free in vivo pharmacokinetics and gene silencing. US20180064749A1.<br>[2]. Samantha M Sarett, et al. Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6490-E6497. |
