DBCO-Sulfo-NHS ester sodium

• CAT Number: I017156
• CAS Number: 1400191-52-7
• Molecular Formula: C₂₅H₂₁N₂NaO₈S
• Molecular Weight: 532.5
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: sodium;1-[6-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-6-oxohexanoyl]oxy-2,5-dioxopyrrolidine-3-sulfonate
• InChI: InChI=1S/C25H22N2O8S.Na/c28-22(11-5-6-12-24(30)35-27-23(29)15-21(25(27)31)36(32,33)34)26-16-19-9-2-1-7-17(19)13-14-18-8-3-4-10-20(18)26;/h1-4,7-10,21H,5-6,11-12,15-16H2,(H,32,33,34);/q;+1/p-1
• InChIKey: QXKHPYSXPCJSPR-UHFFFAOYSA-M
• SMILES: C1C(C(=O)N(C1=O)OC(=O)CCCCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42)S(=O)(=O)[O-].[Na+]

DBCO-Sulfo-NHS ester sodium (Cat.No:I017156) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Reference

[1]. Jung S, et al. Facile strategy for protein conjugation with chitosan-poly(ethylene glycol) hybrid microparticleplatforms via strain-promoted alkyne-azide cycloaddition (SPAAC) reaction. Biomacromolecules. 2013 Nov 11;14(11):3892-902.