dBET6

• CAT Number: I020016
• CAS Number: 1950634-92-0
• Molecular Formula: C₄₂H₄₅ClN₈O₇S
• Molecular Weight: 841.37
• Purity: ≥95%
• Target: Epigenetics
• IUPAC Name: 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[8-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]octyl]acetamide
• InChI: InChI=1S/C42H45ClN8O7S/c1-23-24(2)59-42-35(23)37(26-13-15-27(43)16-14-26)46-29(38-49-48-25(3)50(38)42)21-33(53)44-19-8-6-4-5-7-9-20-45-34(54)22-58-31-12-10-11-28-36(31)41(57)51(40(28)56)30-17-18-32(52)47-39(30)55/h10-16,29-30H,4-9,17-22H2,1-3H3,(H,44,53)(H,45,54)(H,47,52,55)/t29-,30?/m0/s1
• InChIKey: JGQPZPLJOBHHBK-UFXYQILXSA-N
• SMILES: CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NCCCCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O)C7=CC=C(C=C7)Cl)C

dBET6（Cat No.:I020016）is a small molecule that acts as a degrader of BRD4, a protein involved in regulating gene expression and associated with various cancers. By recruiting E3 ligase to BRD4, dBET6 induces the ubiquitination and degradation of BRD4 through the proteasome pathway. This molecule has shown potential in targeting cancers driven by BRD4, including certain types of leukemia and solid tumors. dBET6 is part of a broader class of BET inhibitors, offering a novel therapeutic strategy for diseases where BRD4 plays a pivotal role in tumor progression.

Reference

[1]. Winter GE, et al. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment. Mol Cell. 2017 Jul 6;67(1):5-18.e19.