dBRD9

• CAT Number: I047239
• CAS Number: 2341840-98-8
• Molecular Formula: C40H45N7O10.2ClH
• Molecular Weight: 856.75
• Purity: ≥95%

dBRD9 is a bifunctional molecule that links a small molecule that specifically binds to the bromodomain of BRD9 and another ligand that recruits the cereblon E3 ubiquitin ligase, potently and selectively degrades BRD9 with IC50 of 104 nM in MOLM-13 cells.

Reference

[1] Remillard D, et al. Angew Chem Int Ed Engl. 2017;56(21):5738-5743.