For research use only. Not for therapeutic Use.
DC-TEADin02 is a potent TEAD autopalmitoylation inhibitor. DC-TEADin02 has TEAD autopalmitoylation inhibitory with the IC50 value of 197 nM. DC-TEADin02 can be used for the research of development, regeneration and tissue homeostasis[1].
DC-TEADin02 has TEAD autopalmitoylation inhibitory with the IC50 value of 197 nM[1].
DC-TEADin02 (0-25 μM) inhibits TEADs transcription activity leading to downregulation of YAP-related downstream gene expression[1].
| Catalog Number | I042330 |
| CAS Number | 2380228-45-3 |
| Synonyms | N-[4-(naphthalen-2-ylmethyl)phenyl]ethenesulfonamide |
| Molecular Formula | C19H17NO2S |
| Purity | ≥95% |
| InChI | InChI=1S/C19H17NO2S/c1-2-23(21,22)20-19-11-8-15(9-12-19)13-16-7-10-17-5-3-4-6-18(17)14-16/h2-12,14,20H,1,13H2 |
| InChIKey | IUZGUIPYVGPQFT-UHFFFAOYSA-N |
| SMILES | C=CS(=O)(=O)NC1=CC=C(C=C1)CC2=CC3=CC=CC=C3C=C2 |
| Reference | [1]. Wenchao Lu, et al. Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors. Eur J Med Chem. 2019 Dec 15;184:111767. |
