For research use only. Not for therapeutic Use.
DC1Sme（Cat No.:I019743） is a derivative of DC1, a small molecule analog of the alkylating agent CC-1065. DC1Sme demonstrates potent anticancer activity with low IC50 values against various cancer cell lines. Specifically, its IC50 values against Ramos, Namalwa, HL60/s, and COLO205 cancer cells are 10 pM, 10 pM, 32pM, and 250 pm, respectively. DC1 is known to bind to the minor groove of DNA, and DC1Sme can be used in the synthesis of antibody conjugates, making it a valuable tool for cancer research and targeted therapies.
| Catalog Number | I019743 |
| CAS Number | 501666-85-9 |
| Molecular Formula | C₃₅H₃₀ClN₅O₄S₂ |
| Purity | ≥95% |
| Target | ADC Cytotoxin |
| IUPAC Name | N-[2-[(1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydrobenzo[e]indole-3-carbonyl]-1H-indol-5-yl]-5-[3-(methyldisulfanyl)propanoylamino]-1H-indole-2-carboxamide |
| InChI | InChI=1S/C35H30ClN5O4S2/c1-46-47-11-10-32(43)37-22-6-8-26-19(12-22)14-28(39-26)34(44)38-23-7-9-27-20(13-23)15-29(40-27)35(45)41-18-21(17-36)33-25-5-3-2-4-24(25)31(42)16-30(33)41/h2-9,12-16,21,39-40,42H,10-11,17-18H2,1H3,(H,37,43)(H,38,44)/t21-/m1/s1 |
| InChIKey | TVEHPTDUSKNJAT-OAQYLSRUSA-N |
| SMILES | CSSCCC(=O)NC1=CC2=C(C=C1)NC(=C2)C(=O)NC3=CC4=C(C=C3)NC(=C4)C(=O)N5CC(C6=C5C=C(C7=CC=CC=C76)O)CCl |
| Reference | [1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. |
