For research use only. Not for therapeutic Use.
DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. DCAF1 binder 1 is a ligands for E3 Ligase, involving in targeted protein degradation (TPD)[1].
| Catalog Number | I041370 |
| Synonyms | 1-[4-[4-(2-aminoethylamino)-2-[1-(4-chlorophenyl)cyclohexyl]quinazolin-7-yl]piperazin-1-yl]ethanone |
| Molecular Formula | C28H35ClN6O |
| Purity | ≥95% |
| InChI | InChI=1S/C28H35ClN6O/c1-20(36)34-15-17-35(18-16-34)23-9-10-24-25(19-23)32-27(33-26(24)31-14-13-30)28(11-3-2-4-12-28)21-5-7-22(29)8-6-21/h5-10,19H,2-4,11-18,30H2,1H3,(H,31,32,33) |
| InChIKey | GGEKTDCCHNVLNE-UHFFFAOYSA-N |
| SMILES | CC(=O)N1CCN(CC1)C2=CC3=C(C=C2)C(=NC(=N3)C4(CCCCC4)C5=CC=C(C=C5)Cl)NCCN |
| Reference | [1]. Schroeder M, et al. Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings[J]. bioRxiv, 2023: 2023.04. 09.536153. |
