For research use only. Not for therapeutic Use.
DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of themetabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5) . DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB). DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB)[1].
| Catalog Number | I010478 |
| CAS Number | 6971-97-7 |
| Synonyms | (E)-1-(3-chlorophenyl)-N-[(E)-(3-chlorophenyl)methylideneamino]methanimine |
| Molecular Formula | C14H10Cl2N2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+ |
| InChIKey | XMOVWXSCYLINBJ-BEQMOXJMSA-N |
| SMILES | C1=CC(=CC(=C1)Cl)C=NN=CC2=CC(=CC=C2)Cl |
| Reference | [1]. O’Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003; 64(3):731-40. |
