For research use only. Not for therapeutic Use.
DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl- secretion in T84 colonic cells[1]. DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane Cl- conductance[2].
| Catalog Number | R036296 |
| CAS Number | 60563-36-2 |
| Synonyms | 5,6-dichloro-3-ethyl-1H-benzimidazol-2-one |
| Molecular Formula | C9H8Cl2N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C9H8Cl2N2O/c1-2-13-8-4-6(11)5(10)3-7(8)12-9(13)14/h3-4H,2H2,1H3,(H,12,14) |
| InChIKey | LKHRMULASXZCLG-UHFFFAOYSA-N |
| SMILES | CCN1C2=CC(=C(C=C2NC1=O)Cl)Cl |
| Reference | [1]. Hamilton KL,et al. DCEBIO stimulates Cl- secretion in the mouse jejunum. Am J Physiol Cell Physiol. 2006 Jan;290(1):C152-64. [2]. Singh S, et al. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11. |
