For research use only. Not for therapeutic Use.
dCeMM1 is a RBM39 glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4DCAF15 ligase. dCeMM1 decreases the expression of RBM39 levels in WT KBM7 cells[1].
dCeMM1 (0-100 µM; 3 days) inhibits cell growth with EC50s of 3, 8 µM for WT and UBE2Mmut KBM7 cells, respectively[1].
dCeMM1 (10 µM; 12, 16 h) decreases the expression of RBM39 levels in WT KBM7 cells[1].
| Catalog Number | I042071 |
| CAS Number | 118719-16-7 |
| Synonyms | N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]-4-methylbenzenesulfonamide |
| Molecular Formula | C14H13BrN2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C14H13BrN2O3S/c1-10-2-5-13(6-3-10)21(19,20)17-16-9-11-8-12(15)4-7-14(11)18/h2-9,17-18H,1H3/b16-9+ |
| InChIKey | PBEIAQYKTXKQGF-CXUHLZMHSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)NN=CC2=C(C=CC(=C2)Br)O |
| Reference | [1]. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol. 2020 Nov;16(11):1199-1207. |
