For research use only. Not for therapeutic Use.
dCeMM4 (Compound 5) is a glue degrader. dCeMM4 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex[1].
| Catalog Number | I043870 |
| CAS Number | 1281683-44-0 |
| Synonyms | 3-(5-methylfuran-2-carbonyl)-N-(5-methyl-1,3-thiazol-2-yl)-1,3-thiazolidine-4-carboxamide |
| Molecular Formula | C14H15N3O3S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H15N3O3S2/c1-8-3-4-11(20-8)13(19)17-7-21-6-10(17)12(18)16-14-15-5-9(2)22-14/h3-5,10H,6-7H2,1-2H3,(H,15,16,18) |
| InChIKey | BPWZJVKIVHVVHP-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(O1)C(=O)N2CSCC2C(=O)NC3=NC=C(S3)C |
| Reference | [1]. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling [published correction appears in Nat Chem Biol. 2021 Mar;17(3):361]. Nat Chem Biol. 2020;16(11):1199-1207. |
