DCZ0805

• CAT Number: I047673
• CAS Number: 2361147-16-0
• Molecular Formula: C33H33N2O9P
• Molecular Weight: 632.6
• Purity: ≥95%
• IUPAC Name: methyl (2S)-2-[[[4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenoxy]-[4-[(2-hydroxybenzoyl)amino]phenoxy]phosphoryl]amino]propanoate
• InChI: InChI=1S/C33H33N2O9P/c1-22(33(38)42-4)35-45(39,44-27-17-13-25(14-18-27)34-32(37)30-7-5-6-8-31(30)36)43-26-15-11-23(12-16-26)9-10-24-19-28(40-2)21-29(20-24)41-3/h5-22,36H,1-4H3,(H,34,37)(H,35,39)/b10-9+/t22-,45?/m0/s1
• SMILES: C[C@@H](C(=O)OC)NP(=O)(OC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC)OC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4O

DCZ0805 is a suppressor of the NF-κB signaling pathway activation. DCZ0805 treatment arrested the cell at the G0/G1 phase and suppressed multiple myeloma cells survival by inducing apoptosis via extrinsic and intrinsic pathways.
KEYWORDS: DCZ0805 | Supplier | NF-κB inhibitor | DCZ 0805 | DCZ-0805 | CAS [2361147-16-0] | Non Selective | NF-κB | Inhibitor | Transcription Factors | Multiple myeloma

Reference

X Gao et al. A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-κB pathway. Cancer Cell Int. 2021 May 30;21(1):285.