For research use only. Not for therapeutic Use.
DDO-6600 is a targeted covalent inhibitor of heat shock protein 90 (Hsp90). DDO-6600 covalently bound to Cys598 on the Hsp90 C terminus and exhibited antiproliferative activities against multiple tumor cells without inhibiting ATPase activity.
KEYWORDS: DDO-6600 | Supplier | Hsp90 inhibitor | DDO 6600 | DDO6600 | CAS [2640292-37-9] | [1025495-87-7] | Unfolded Protein Response (Non Selective) | Hsp90 | Inhibitor | Enzymes | TCI | Chaperone
| Catalog Number | I047659 |
| CAS Number | 2640292-37-9 |
| Molecular Formula | C26H28N4O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[(E)-3-[3-(3,4-dimethylphenyl)-1-phenylpyrazol-4-yl]prop-2-enoyl]piperidine-2-carboxamide |
| InChI | InChI=1S/C26H28N4O2/c1-18-11-12-20(16-19(18)2)25-21(17-30(28-25)22-8-4-3-5-9-22)13-14-24(31)29-15-7-6-10-23(29)26(27)32/h3-5,8-9,11-14,16-17,23H,6-7,10,15H2,1-2H3,(H2,27,32)/b14-13+ |
| SMILES | CC1=C(C=C(C=C1)C2=NN(C=C2/C=C/C(=O)N3CCCCC3C(=O)N)C4=CC=CC=C4)C |
| Reference | L Li et al. Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification. Cell Chem Biol. 2021 Oct 21;28(10):1446-1459.e6. |
