DDR Inhibitor

• CAT Number: I020140
• CAS Number: 1644069-80-6
• Molecular Formula: C₂₃H₂₀FN₅O₂
• Molecular Weight: 417.44
• Purity: ≥95%
• Target: Discoidin Domain Receptor
• IUPAC Name: N-[5-[[(3-fluorophenyl)carbamoylamino]methyl]-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide
• InChI: InChI=1S/C23H20FN5O2/c1-15-8-9-16(13-26-23(31)27-18-6-4-5-17(24)12-18)11-19(15)28-22(30)20-14-25-21-7-2-3-10-29(20)21/h2-12,14H,13H2,1H3,(H,28,30)(H2,26,27,31)
• InChIKey: ZPVUIOVIUFJGHO-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)CNC(=O)NC2=CC(=CC=C2)F)NC(=O)C3=CN=C4N3C=CC=C4

DDR Inhibitor (Cat.No:I020140) is a compound that selectively targets and inhibits the DNA damage response (DDR) pathway. By disrupting DDR signaling, it can enhance the sensitivity of cancer cells to chemotherapy and radiation therapy. Further research is ongoing to evaluate its potential as an anticancer treatment. 

Reference

[1]. Gordon Saxty, et al. Imidazo-condensed bicycles as inhibitors of discoidin domain receptors (ddrs)