DDR1-IN-5

• CAT Number: I015272
• CAS Number: 2416022-90-5
• Molecular Formula: C22H13F3N6O
• Molecular Weight: 434.37
• Purity: ≥95%
• Synonyms: 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[5-(trifluoromethyl)pyridin-3-yl]-1,2-benzoxazol-3-amine
• InChI: InChI=1S/C22H13F3N6O/c1-13-4-6-18-20(17(13)7-5-16-12-27-19-3-2-8-28-31(16)19)32-30-21(18)29-15-9-14(10-26-11-15)22(23,24)25/h2-4,6,8-12H,1H3,(H,29,30)
• InChIKey: LGHRUPKASNQBFS-UHFFFAOYSA-N
• SMILES: CC1=C(C2=C(C=C1)C(=NO2)NC3=CN=CC(=C3)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity[1]. DDR1-IN-5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
DDR1-IN-5 (compound 121; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=62 nM)[1].
DDR1-IN-5 (72 hours) has cytotoxicity in LX-2 cells (CC50>40 μM)[1].

Reference

[1]. Aleksandr M. Aliper, et al. Kinase inhibitors. WO2020079652A1.