DDX3-IN-1

• CAT Number: I018739
• CAS Number: 1919828-83-3
• Molecular Formula: C₁₇H₁₇N₅O
• Molecular Weight: 307.35
• Purity: ≥95%
• Target: HIV
• Storage: Store at -20°C
• IUPAC Name: 1-(2-methylphenyl)-3-[4-(4-methyltriazol-1-yl)phenyl]urea
• InChI: InChI=1S/C17H17N5O/c1-12-5-3-4-6-16(12)19-17(23)18-14-7-9-15(10-8-14)22-11-13(2)20-21-22/h3-11H,1-2H3,(H2,18,19,23)
• InChIKey: YIIUGRJFJAHCFZ-UHFFFAOYSA-N
• SMILES: CC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)N3C=C(N=N3)C

DDX3-IN-1（Cat No.:I018739）is a selective small-molecule inhibitor targeting DDX3, a DEAD-box RNA helicase implicated in various cellular processes, including mRNA translation, splicing, and viral replication. By inhibiting DDX3 activity, this compound disrupts key pathways involved in cancer progression, viral infections, and immune modulation. DDX3-IN-1 has shown potential in preclinical studies for its anti-tumor and antiviral effects, particularly against RNA viruses. Its specificity and efficacy make it a valuable tool for exploring DDX3’s biological functions and developing novel therapeutic strategies in oncology and infectious disease research.

Reference

[1]. Brai A, et al. Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents. Proc Natl Acad Sci U S A. 2016 May 10;113(19):5388-93.