DDX3-IN-1

• CAT Number: I018739
• CAS Number: 1919828-83-3
• Molecular Formula: C₁₇H₁₇N₅O
• Molecular Weight: 307.35
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 1-(2-methylphenyl)-3-[4-(4-methyltriazol-1-yl)phenyl]urea
• InChI: InChI=1S/C17H17N5O/c1-12-5-3-4-6-16(12)19-17(23)18-14-7-9-15(10-8-14)22-11-13(2)20-21-22/h3-11H,1-2H3,(H2,18,19,23)
• InChIKey: YIIUGRJFJAHCFZ-UHFFFAOYSA-N
• SMILES: CC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)N3C=C(N=N3)C

DDX3-IN-1 (Cat No.:I018739) is a small molecule inhibitor of the DEAD-box RNA helicase DDX3, a multifunctional protein that plays important roles in RNA metabolism, translation initiation, and innate immune response. DDX3 is involved in various diseases, including cancer, viral infections, and neurodegenerative disorders. DDX3-IN-1 selectively inhibits DDX3 ATPase activity with an IC50 of 0.43 μM and shows antiviral activity against hepatitis C virus (HCV) and Zika virus (ZIKV) in cell culture models.

Reference

[1]. Brai A, et al. Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents. Proc Natl Acad Sci U S A. 2016 May 10;113(19):5388-93.