Deacetyl-N-monodemethyldiltiazem

• CAT Number: I025669
• CAS Number: 40861-80-1
• Molecular Formula: C19H23ClN2O3S
• Molecular Weight: 394.91
• Purity: 98%
• Synonyms: Deacetyl-N-monodemethyldiltiazem
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-hydroxy-2-(4-methoxyphenyl)-5-[2-(methylamino)ethyl]-2,3-dihydro-1,5-benzothiazepin-4-one;hydrochloride
• InChI: InChI=1S/C19H22N2O3S.ClH/c1-20-11-12-21-15-5-3-4-6-16(15)25-18(17(22)19(21)23)13-7-9-14(24-2)10-8-13;/h3-10,17-18,20,22H,11-12H2,1-2H3;1H
• InChIKey: WRRTVAXYYSGAOT-UHFFFAOYSA-N
• SMILES: CNCCN1C2=CC=CC=C2SC(C(C1=O)O)C3=CC=C(C=C3)OC.Cl

Deacetyl-N-monodemethyldiltiazem（Cat No.:I025669）is a metabolite of diltiazem, a calcium channel blocker commonly used to treat hypertension and angina. The compound is formed when diltiazem undergoes hepatic metabolism, specifically deacetylation and demethylation. This metabolite retains some pharmacological activity and contributes to the drug’s overall therapeutic effects, although it is less potent than the parent compound. Deacetyl-N-monodemethyldiltiazem is of interest in pharmacokinetic studies to better understand the metabolism of diltiazem and its long-term effects on blood pressure regulation and cardiovascular health. Its role and impact on clinical outcomes are further investigated in pharmacology research.