Deamino-hydroxytamoxifen

• CAT Number: I025688
• CAS Number: 77207-49-9
• Molecular Formula: C24H24O2
• Molecular Weight: 344.45
• Purity: 98%
• Synonyms: Deamino-hydroxytamoxifen; Deamino hydroxytamoxifen; Tamoxifen metabolite Y; Tamoxifen-ol.
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]ethanol
• InChI: InChI=1S/C24H24O2/c1-2-23(19-9-5-3-6-10-19)24(20-11-7-4-8-12-20)21-13-15-22(16-14-21)26-18-17-25/h3-16,25H,2,17-18H2,1H3/b24-23-
• InChIKey: TWASUFZMILCYJY-VHXPQNKSSA-N
• SMILES: CC/C(=C(\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCO)/C3=CC=CC=C3

Deamino-hydroxytamoxifen（Cat No.:I025688）is a derivative of tamoxifen, a selective estrogen receptor modulator (SERM) widely used in the treatment of estrogen receptor-positive breast cancer. This compound is an active metabolite of tamoxifen, lacking the amino group of its parent compound. It retains tamoxifen’s ability to block estrogen receptors on tumor cells, thereby inhibiting cancer cell growth. Deamino-hydroxytamoxifen is often studied for its enhanced potency and potentially improved pharmacological properties compared to tamoxifen. It may have applications in cancer therapy, particularly for tamoxifen-resistant breast cancers, though further clinical research is needed to assess its effectiveness and safety.

Reference

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