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21860-31-1-Decursinol, (-)- Decursinol, (-)-

Decursinol, (-)-

For research use only. Not for therapeutic Use.

  • CAT Number: I025819
  • CAS Number: 21860-31-1
  • Molecular Formula: C14H14O4
  • Molecular Weight: 246.26
  • Purity: 98%
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Related Small Molecules: MoTP     UBX1325     Hetrombopag    

Decursinol, (-)- is a biochemical.


Catalog Number I025819
CAS Number 21860-31-1
Synonyms

Decursinol, (-)-; (-)-Decursinol; (-)-Smyrinol; Aegelinol; UNII-I65EAN940H.

Molecular Formula C14H14O4
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name (R)-7-hydroxy-8,8-dimethyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one
InChI InChI=1S/C14H14O4/c1-14(2)12(15)6-9-5-8-3-4-13(16)17-10(8)7-11(9)18-14/h3-5,7,12,15H,6H2,1-2H3/t12-/m1/s1
InChIKey BGXFQDFSVDZUIW-GFCCVEGCSA-N
SMILES CC1(C)Oc2cc3OC(=O)C=Cc3cc2C[C@H]1O
Reference

1: Kim S, Kim JE, Kim N, Joo M, Lee MW, Jeon HJ, Ryu H, Song IC, Song GY, Lee HJ. Decursin inhibits tumor growth, migration, and invasion in gastric cancer by down-regulating CXCR7 expression. Am J Cancer Res. 2019 Sep 1;9(9):2007-2018. eCollection 2019. PubMed PMID: 31598401; PubMed Central PMCID: PMC6780662.
2: Kwon MY, Park J, Kim SM, Lee J, Cho H, Park JH, Han IO. An alpha-lipoic acid-decursinol hybrid compound attenuates lipopolysaccharide-mediated inflammation in BV2 and RAW264.7 cells. BMB Rep. 2019 Aug;52(8):508-513. PubMed PMID: 31383251; PubMed Central PMCID: PMC6726214.
3: Chang SN, Khan I, Dey DK, Cho KH, Hwang BS, Bae KB, Kang SC, Park JG. Decursinol angelate ameliorates 12-O-tetradecanoyl phorbol-13-acetate (TPA) -induced NF-κB activation on mice ears by inhibiting exaggerated inflammatory cell infiltration, oxidative stress and pro-inflammatory cytokine production. Food Chem Toxicol. 2019 Oct;132:110699. doi: 10.1016/j.fct.2019.110699. Epub 2019 Jul 24. PubMed PMID: 31351099.
4: Jung MY, Seo CS, Baek SE, Lee J, Shin MS, Kang KS, Lee S, Yoo JE. Analysis and Identification of Active Compounds from Gami-Soyosan Toxic to MCF-7 Human Breast Adenocarcinoma Cells. Biomolecules. 2019 Jul 10;9(7). pii: E272. doi: 10.3390/biom9070272. PubMed PMID: 31295870; PubMed Central PMCID: PMC6681368.
5: Kiyonga AN, An JH, Lee KY, Lim C, Suh YG, Chin YW, Jung K. Rapid and Efficient Separation of Decursin and Decursinol Angelate from Angelica gigas Nakai using Ionic Liquid, (BMIm)BF(4), Combined with Crystallization. Molecules. 2019 Jun 28;24(13). pii: E2390. doi: 10.3390/molecules24132390. PubMed PMID: 31261662; PubMed Central PMCID: PMC6651083.
6: Thapa B, Pak S, Kwon HJ, Lee K. Decursinol Angelate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Modulating Type 17 Helper T Cell Responses. Biomol Ther (Seoul). 2019 Mar 25;27(5):466-473. doi: 10.4062/biomolther.2019.004. [Epub ahead of print] PubMed PMID: 30917627; PubMed Central PMCID: PMC6720537.
7: Lee W, Yuseok O, Lee C, Jeong SY, Lee JH, Baek MC, Song GY, Bae JS. Suppressive activities of KC1-3 on HMGB1-mediated septic responses. Biochem Pharmacol. 2019 May;163:260-268. doi: 10.1016/j.bcp.2019.02.027. Epub 2019 Feb 26. PubMed PMID: 30822402.
8: Evidence-Based Complementary And Alternative Medicine. Retracted: Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK. Evid Based Complement Alternat Med. 2019 Jan 2;2019:2986594. doi: 10.1155/2019/2986594. eCollection 2019. PubMed PMID: 30719058; PubMed Central PMCID: PMC6334345.
9: Oh ST, Lee S, Hua C, Koo BS, Pak SC, Kim DI, Jeon S, Shin BA. Decursin induces apoptosis in glioblastoma cells, but not in glial cells via a mitochondria-related caspase pathway. Korean J Physiol Pharmacol. 2019 Jan;23(1):29-35. doi: 10.4196/kjpp.2019.23.1.29. Epub 2018 Dec 26. PubMed PMID: 30627007; PubMed Central PMCID: PMC6315092.
10: Azad MOK, Piao JP, Park CH, Cho DH. Far Infrared Irradiation Enhances Nutraceutical Compounds and Antioxidant Properties in Angelica gigas Nakai Powder. Antioxidants (Basel). 2018 Dec 11;7(12). pii: E189. doi: 10.3390/antiox7120189. PubMed PMID: 30545026; PubMed Central PMCID: PMC6315959.
11: Fontamillas GAD, Kim SW, Kim HU, Kim SJ, Kim JG, Park TS, Park BC. Effects of Angelica gigas Nakai on the production of decursin- and decursinol angelate-enriched eggs. J Sci Food Agric. 2019 Apr;99(6):3117-3123. doi: 10.1002/jsfa.9526. Epub 2019 Jan 31. PubMed PMID: 30536922.
12: Lee W, Yuseok O, Yang S, Lee BS, Lee JH, Park EK, Baek MC, Song GY, Bae JS. JH-4 reduces HMGB1-mediated septic responses and improves survival rate in septic mice. J Cell Biochem. 2019 Apr;120(4):6277-6289. doi: 10.1002/jcb.27914. Epub 2018 Oct 30. PubMed PMID: 30378167.
13: Li J, Wang H, Wang L, Tan R, Zhu M, Zhong X, Zhang Y, Chen B, Wang L. Decursin inhibits the growth of HepG2 hepatocellular carcinoma cells via Hippo/YAP signaling pathway. Phytother Res. 2018 Dec;32(12):2456-2465. doi: 10.1002/ptr.6184. Epub 2018 Sep 24. PubMed PMID: 30251417.
14: Jeon YJ, Shin JI, Lee S, Lee YG, Kim JB, Kwon HC, Kim SH, Kim I, Lee K, Han YS. Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis. Biomed Res Int. 2018 Aug 1;2018:6716547. doi: 10.1155/2018/6716547. eCollection 2018. PubMed PMID: 30155480; PubMed Central PMCID: PMC6093040.
15: Islam SU, Lee JH, Shehzad A, Ahn EM, Lee YM, Lee YS. Decursinol Angelate Inhibits LPS-Induced Macrophage Polarization through Modulation of the NFκB and MAPK Signaling Pathways. Molecules. 2018 Jul 27;23(8). pii: E1880. doi: 10.3390/molecules23081880. PubMed PMID: 30060484; PubMed Central PMCID: PMC6222640.
16: Kim HJ, Lee GJ, Choi AJ, Kim TH, Kim TI, Oh JM. Layered Double Hydroxide Nanomaterials Encapsulating Angelica gigas Nakai Extract for Potential Anticancer Nanomedicine. Front Pharmacol. 2018 Jul 9;9:723. doi: 10.3389/fphar.2018.00723. eCollection 2018. PubMed PMID: 30038570; PubMed Central PMCID: PMC6046438.
17: Kim E, Nam J, Chang W, Zulfugarov IS, Okhlopkova ZM, Olennikov D, Chirikova NK, Kim SW. Angelica gigas Nakai and Decursin Downregulate Myc Expression to Promote Cell Death in B-cell Lymphoma. Sci Rep. 2018 Jul 12;8(1):10590. doi: 10.1038/s41598-018-28619-z. PubMed PMID: 30002430; PubMed Central PMCID: PMC6043616.
18: Kim YJ, Jeong SJ, Seo CS, Lim HS, Sohn E, Yun J, Kim BY. Simultaneous Determination of the Traditional Herbal Formula Ukgansan and the In Vitro Antioxidant Activity of Ferulic Acid as an Active Compound. Molecules. 2018 Jul 7;23(7). pii: E1659. doi: 10.3390/molecules23071659. PubMed PMID: 29986512; PubMed Central PMCID: PMC6100485.
19: Park Y, Kim D, Yang I, Choi B, Lee JW, Namkoong S, Koo HJ, Lee SR, Park MR, Lim H, Kim YK, Nam SJ, Sohn EH. Decursin and Z-Ligustilide in Angelica tenuissima Root Extract Fermented by Aspergillus oryzae Display Anti-Pigment Activity in Melanoma Cells. J Microbiol Biotechnol. 2018 Jul 28;28(7):1061-1067. doi: 10.4014/jmb.1812.02044. PubMed PMID: 29913552.
20: Nam S, Lee SY, Kang WS, Cho HJ. Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer. Nanomaterials (Basel). 2018 May 31;8(6). pii: E384. doi: 10.3390/nano8060384. PubMed PMID: 29857475; PubMed Central PMCID: PMC6027326.

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