For research use only. Not for therapeutic Use.
Decylubiquinone (Cat.No:I006356) is an analog of ubiquinone. Decylubiquinone increases mitochondrial function in synaptosomes. decylubiquinone inhibits the redox-activated mitochondrial permeability transition. It blocks reactive oxygen species production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition.
| Catalog Number | I006356 |
| CAS Number | 55486-00-5 |
| Synonyms | Decylubiquinone;2-decyl-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione |
| Molecular Formula | C19H30O4 |
| Purity | ≥95% |
| Target | NF-κB |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione |
| InChI | InChI=1S/C19H30O4/c1-5-6-7-8-9-10-11-12-13-15-14(2)16(20)18(22-3)19(23-4)17(15)21/h5-13H2,1-4H3 |
| InChIKey | VMEGFMNVSYVVOM-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCC1=C(C(=O)C(=C(C1=O)OC)OC)C |
| Reference | </br>1:Decylubiquinone increases mitochondrial function in synaptosomes. Telford JE, Kilbride SM, Davey GP.J Biol Chem. 2010 Mar 19;285(12):8639-45. doi: 10.1074/jbc.M109.079780. Epub 2010 Jan 14. PMID: 20080966 Free PMC Article</br>2:Effects of decylubiquinone (coenzyme Q10 analog) supplementation on SHRSP. Murad LB, Guimarães MR, Vianna LM.Biofactors. 2007;30(1):13-8. PMID: 18198397 </br>3:The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III. Armstrong JS, Whiteman M, Rose P, Jones DP.J Biol Chem. 2003 Dec 5;278(49):49079-84. Epub 2003 Aug 29. PMID: 12949071 Free Article</br>4:Mutagenesis of subunit N of the Escherichia coli complex I. Identification of the initiation codon and the sensitivity of mutants to decylubiquinone. Amarneh B, Vik SB.Biochemistry. 2003 May 6;42(17):4800-8. PMID: 12718520 </br>5:Electrogenic proton transfer in Rhodobacter sphaeroides reaction centers: effect of coenzyme Q(10) substitution by decylubiquinone in the Q(B) binding site. Gopta OA, Semenov AY, Bloch DA.FEBS Lett. 2001 Jun 15;499(1-2):116-20. Erratum in: FEBS Lett 2002 Apr 24;517(1-3):288. PMID: 11418124 Free Article</br>6:Micelle-supported electroenzymology: Succinate dehydrogenation by escherichia coli fumarate reductase in decylubiquinone and octyl glucoside micelles. Kinnear KT, Monbouquette HG.Biotechnol Bioeng. 1993 Jun 5;42(1):140-4. PMID: 18609658 |
