Defactinib hydrochloride

• CAT Number: I000338
• CAS Number: 1073160-26-5
• Molecular Formula: C20H22ClF3N8O3S
• Molecular Weight: 546.95
• Purity: ≥95%
• Target: FAK
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

Defactinib hydrochloride(CAT: I000338) is a chemical compound that is also known as VS-6063 hydrochloride. It is an orally bioavailable small molecule inhibitor of the focal adhesion kinase (FAK). FAK is a protein kinase that plays a role in cell adhesion, migration, and survival. By inhibiting FAK, defactinib hydrochloride can potentially disrupt these cellular processes and inhibit tumor growth and metastasis. Defactinib hydrochloride has been investigated as a potential therapeutic agent in various cancers, including pancreatic cancer, ovarian cancer, and mesothelioma.

Reference

[1]. Kang Y, et al. Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95.