Deferitazole

• CAT Number: I006419
• CAS Number: 945635-15-4
• Molecular Formula: C18H25NO7S
• Molecular Weight: 399.458
• Purity: ≥95%
• Synonyms: FBS-0701; FBS0701; FBS 0701; SPD-602; SPD 602; SPD602; Deferitazole;(S)-2-(2-hydroxy-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-4-methyl-4,5-dihydrothiazole-4-carboxylic acid
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: (2Z,4S)-2-[5-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-6-oxocyclohexa-2,4-dien-1-ylidene]-4-methyl-1,3-thiazolidine-4-carboxylic acid
• InChI: InChI=1S/C18H25NO7S/c1-18(17(21)22)12-27-16(19-18)13-4-3-5-14(15(13)20)26-11-10-25-9-8-24-7-6-23-2/h3-5,19H,6-12H2,1-2H3,(H,21,22)/b16-13-/t18-/m1/s1
• InChIKey: IBDVQJPMBDDQTO-BBLCHGJFSA-N
• SMILES: CC1(CSC(=C2C=CC=C(C2=O)OCCOCCOCCOC)N1)C(=O)O

Deferitazole, also known as FBS-0701 and SPD-602, is a new orally active Antimalarial iron chelator for the treatment of transfusional iron overload. Deferitazole displays a high affinity and selectivity for iron(III) as demonstrated by the log β2 = 33.39 ± 0.03 and the pFe(3+) value of 22.3. Deferitazole scavenges iron from labile sources such as citrate and albumin with efficiencies comparable with those of other therapeutic iron chelators, including deferasirox, deferiprone and desferrioxamine. FBS0701 blocks transmission by Plasmodium falciparum gametocyte.