For research use only. Not for therapeutic Use.
Deferitrin (Cat.No:I006421), also known as GT-56252, is an iron chelator potentially for the treatment of thelassemia and iron overload.
| Catalog Number | I006421 |
| CAS Number | 239101-33-8 |
| Synonyms | GT-56-252; GT 56 252; GT-56252; GT 56252;4,5-Dihydro-2-(2,4-dihydroxyphenyl)-4-methylthiazol-4-(S)-carboxylic acid |
| Molecular Formula | C11H11NO4S |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | (4S)-2-(2,4-dihydroxyphenyl)-4-methyl-5H-1,3-thiazole-4-carboxylic acid |
| InChI | InChI=1S/C11H11NO4S/c1-11(10(15)16)5-17-9(12-11)7-3-2-6(13)4-8(7)14/h2-4,13-14H,5H2,1H3,(H,15,16)/t11-/m1/s1 |
| InChIKey | OEUUFNIKLCFNLN-LLVKDONJSA-N |
| SMILES | C[C@@]1(CSC(=N1)C2=C(C=C(C=C2)O)O)C(=O)O |
| Reference | </br>1:Drug evaluation: Deferitrin for iron overload disorders. Barton JC.IDrugs. 2007 Jul;10(7):480-90. PMID: 17642018 </br>2:Drug evaluation: deferitrin (GT-56-252; NaHBED) for iron overload disorders. Barton JC.IDrugs. 2007 Apr;10(4):270-81. Review. PMID: 17390251 </br>3:Preclinical and clinical development of deferitrin, a novel, orally available iron chelator. Donovan JM, Plone M, Dagher R, Bree M, Marquis J.Ann N Y Acad Sci. 2005;1054:492-4. Review. PMID: 16339704 |
