For research use only. Not for therapeutic Use.
Deflazacort (Cat No.:A000573) is a synthetic corticosteroid medication used for its anti-inflammatory and immunosuppressive effects. It is prescribed to treat a variety of inflammatory and autoimmune conditions, including allergies, asthma, rheumatoid arthritis, and inflammatory bowel disease. Deflazacort helps to reduce inflammation, swelling, and immune responses by modifying gene expression and inhibiting certain enzymes. It is often chosen for its lower potential to cause certain side effects compared to other corticosteroids.
Catalog Number | A000573 |
CAS Number | 14484-47-0 |
Synonyms | MDL 458; 14484-47-0; Azacort; Calcort; Oxazacort; Flantadin |
Molecular Formula | C25H31NO6 |
Purity | ≥95% |
Target | Vitamin D Related/Nuclear Receptor |
Storage | 2-8°C |
IUPAC Name | [2-[(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-6,9,13-trimethyl-16-oxo-5-oxa-7-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-6,14,17-trien-8-yl]-2-oxoethyl] acetate |
InChI | InChI=1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1 |
InChIKey | FBHSPRKOSMHSIF-GRMWVWQJSA-N |
SMILES | CC1=NC2(C(O1)CC3C2(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)C(=O)COC(=O)C |
Reference | 1: Deflazacort (Emflaza) for Duchenne muscular dystrophy. Med Lett Drugs Ther. <br> 3: Gupta N, Ganpati A, Mandal S, Mathew J, Goel R, Mathew AJ, Nair A, Ramasamy P, 4: Escudero AI, Marín P, Cárceles CM, Escudero E. Pharmacokinetics of deflazacort 5: Jensen L, Petersson SJ, Illum NO, Laugaard-Jacobsen HC, Thelle T, Jørgensen 6: Deshmukh R, Sharma L, Tekade M, Kesharwani P, Trivedi P, Tekade RK. Force 7: Traynor K. Deflazacort approved for Duchenne muscular dystrophy. Am J Health 8: Parente L. Deflazacort: therapeutic index, relative potency and equivalent 9: Raju CK, Pandey AK, Ghosh K, Pola A, Goud SK, Jaywant MA, Navalgund SG, 10: Petnikota H, Madhuri V, Gangadharan S, Agarwal I, Antonisamy B. Retrospective |