Dehydroandrographolide

• CAT Number: I001313
• CAS Number: 134418-28-3
• Molecular Formula: C20H28O4
• Molecular Weight: 332.43
• Purity: ≥95%
• Target: Influenza Virus
• Solubility: 10 mM in ethanol
• Storage: Store at -20°C
• IUPAC Name: (3E)-3-[2-[(1S,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]furan-2-one
• InChI: InChI=1S/C20H28O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h5,9,11,15-17,21-22H,1,4,6-8,10,12H2,2-3H3/b14-5+/t15-,16-,17+,19-,20-/m0/s1
• InChIKey: YIIRVUDGRKEWBV-CZUXAOBFSA-N
• SMILES: C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@@H]2C/C=C/3\C=COC3=O)(C)CO)O

Dehydroandrographolide（Cat No.:I001313）is a diterpenoid compound derived from Andrographis paniculata, known for its anti-inflammatory, antiviral, and hepatoprotective properties. It is widely studied for its potential to modulate immune responses and inhibit pro-inflammatory cytokines, making it useful in managing inflammatory conditions and viral infections. Dehydroandrographolide also exhibits antioxidant activity, aiding in liver protection and detoxification. With a favorable safety profile and broad pharmacological actions, it is used in traditional and modern medicine for supporting immune health and treating conditions like viral hepatitis, upper respiratory infections, and other inflammatory diseases.

Reference

[1]. Chen Q, et al. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenous administration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012 Oct;33(10):1332-6.

[2]. Chao WW, et al. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med. 2010 May 13;5:17.

[3]. Basak A, et al. Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Biochem J. 1999 Feb 15;338 ( Pt 1):107-13.

[4]. Zhu T, et al. Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1238-41.

[5]. Chen H, et al. Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents. Bioorg Med Chem Lett. 2014 May 15;24(10):2353-9.