Dehydrocostus Lactone

• CAT Number: I003666
• CAS Number: 477-43-0
• Molecular Formula: C15H18O2
• Molecular Weight: 230.3
• Purity: ≥95%
• Synonyms: (-)-Dehydrocostus lactone
• Target: Disease Research Fields
• Solubility: 10 mM in DMSO
• Storage: -20°C
• InChIKey: NETSQGRTUNRXEO-XUXIUFHCSA-N

Dehydrocostus lactone (CAT: I003666) is a natural compound derived from the plant Costus speciosus. It is classified as a sesquiterpene lactone and is known for its various biological activities. Dehydrocostus lactone has been studied for its anti-inflammatory, antioxidant, and anticancer properties. It has shown potential in inhibiting the production of inflammatory mediators and reducing oxidative stress. Additionally, dehydrocostus lactone has exhibited cytotoxic effects on certain cancer cells, suggesting its potential as an anticancer agent. Further research is ongoing to explore its therapeutic applications and mechanisms of action.

Reference

[1]. Eun Ji Kim, et al. Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. Food and Chemical Toxicology
Volume 46, Issue 12, December 2008, Pages 3651–3658

[2]. Oh GS, et al. Dehydrocostus lactone enhances tumor necrosis factor-alpha-induced apoptosis of human leukemia HL-60 cells. Immunopharmacol Immunotoxicol. 2004 May;26(2):163-75.

[3]. Lee HJ, et al. A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. Planta Med. 1999 Mar;65(2):104-8.

[4]. Taniguchi M, et al. COSTUNOLIDE AND DEHYDROCOSTUS LACTONE AS INHIBITORS OF KILLING FUNCTION OF CYTOTOXIC T LYMPHOCYTES. Bioscience, Biotechnology, and Biochemistry, 1995, 59 (11): 2064-2067