DEL-22379

• CAT Number: I002355
• CAS Number: 181223-80-3
• Molecular Formula: C₂₆H₂₈N₄O₃
• Molecular Weight: 444.53
• Purity: ≥95%
• Synonyms: N-(3-((5-methoxy-1H-indol-3-yl)methylene)-2-oxoindolin-5-yl)-3-(piperidin-1-yl)propanamide
• Target: ERK
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: -20°C
• IC50: 0.5 μM
• IUPAC Name: N-[(3Z)-3-[(5-methoxy-1H-indol-3-yl)methylidene]-2-oxo-1H-indol-5-yl]-3-piperidin-1-ylpropanamide
• InChI: InChI=1S/C26H28N4O3/c1-33-19-6-8-23-20(15-19)17(16-27-23)13-22-21-14-18(5-7-24(21)29-26(22)32)28-25(31)9-12-30-10-3-2-4-11-30/h5-8,13-16,27H,2-4,9-12H2,1H3,(H,28,31)(H,29,32)/b22-13-
• InChIKey: INQUULPXCZAKMS-XKZIYDEJSA-N
• SMILES: COC1=CC2=C(C=C1)NC=C2/C=C\3/C4=C(C=CC(=C4)NC(=O)CCN5CCCCC5)NC3=O

DEL-22379（Cat No.:I002355）is a selective inhibitor of ERK1/2 dimerization, blocking the extracellular signal-regulated kinases, which are crucial in the MAPK/ERK signaling pathway. By inhibiting ERK dimerization, DEL-22379 disrupts downstream signaling processes that regulate cell proliferation, differentiation, and survival. This compound is significant in cancer research, particularly in targeting ERK-driven tumors such as those with RAS or RAF mutations. Its role in preclinical studies helps researchers explore potential therapeutic interventions for cancers where abnormal MAPK/ERK signaling is a key factor in disease progression.

Reference

[1]. Herrero A, et al. Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell. 2015 Aug 10;28(2):170-82.