Delavirdine mesylate

• CAT Number: I001794
• CAS Number: 147221-93-0
• Molecular Formula: C23H32N6O6S2
• Molecular Weight: 552.67
• Purity: ≥95%
• Synonyms: methanesulfonic acid;N-[2-[4-[3-(propan-2-ylamino)pyridin-2-yl]piperazine-1-carbonyl]-1H-indol-5-yl]methanesulfonamide
• Target: HIV
• Solubility: DMSO: ≥ 40.3 mg/mL
• Storage: Store at -20C
• IC50: 0.26 uM (Recombinant HIV-1 RT) [1]
• InChI: InChI=1S/C22H28N6O3S.CH4O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20;1-5(2,3)4/h4-8,13-15,24-26H,9-12H2,1-3H3;1H3,(H,2,3,4)
• InChIKey: MEPNHSOMXMALDZ-UHFFFAOYSA-N
• SMILES: CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C.CS(=O)(=O)O

Delavirdine mesylate（Cat No.:I001794）is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infection. It works by binding directly to reverse transcriptase, inhibiting the replication of viral RNA into DNA, an essential step in the HIV life cycle. Typically used in combination antiretroviral therapy, delavirdine mesylate enhances efficacy and reduces resistance development. Its oral bioavailability and ability to target drug-resistant HIV strains make it a valuable option in managing HIV. Ongoing research explores its pharmacological profile to optimize therapeutic outcomes in antiretroviral regimens.

Reference

[1]. Dueweke TJ, et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother. 1993 May;37(5):1127-31.
[2]. Voorman RL, et al. Interaction of delavirdine with human liver microsomal cytochrome P450: inhibition of CYP2C9, CYP2C19, and CYP2D6. Drug Metab Dispos. 2001 Jan;29(1):41-7.
[3]. Shelton MJ, et al. Pharmacokinetics of ritonavir and delavirdine in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 2003 May;47(5):1694-9.