Delta-Tocopherol

• CAT Number: R046475
• CAS Number: 119-13-1
• Molecular Formula: C27H46O2
• Molecular Weight: 402.65
• Purity: ≥95%
• Synonyms: (2R)-2,8-dimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
• InChI: InChI=1S/C27H46O2/c1-20(2)10-7-11-21(3)12-8-13-22(4)14-9-16-27(6)17-15-24-19-25(28)18-23(5)26(24)29-27/h18-22,28H,7-17H2,1-6H3/t21-,22-,27-/m1/s1
• InChIKey: GZIFEOYASATJEH-VHFRWLAGSA-N
• SMILES: CC1=CC(=CC2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)O

Delta-Tocopherol is an isomer of Vitamin E[1].
Delta-Tocopherol (0-100 μM, 96 h) inhibits cell growth and induces apoptosis in human prostate cancer LNCaP cells[2].
Delta-Tocopherol (0-100 μM, 24 h) inhibits DHT (10 nM) -induced androgen receptor activation and its downstream target PSA in CWR-22Rv1/AR cells[2].
Delta-Tocopherol (10 μM, 1-4 days) decreases estrogen induced cyclin D1 and c-Myc levels in MCF-7 cells and MDA-MB-231 cells[3].
Delta-Tocopherol (0.2% supplemented in diet, 28 weeks) inhibits the development of prostate adenocarcinoma in Ptenp−/− mice[1].
Delta-Tocopherol (0.2% supplemented in diet, 5 weeks) inhibits tumor growth in MCF-7 xenograft model[1].

Reference

[1]. Wang H, et al. δ-Tocopherol inhibits the development of prostate adenocarcinoma in prostate specific Pten-/- mice. Carcinogenesis. 2018 Feb 9;39(2):158-169.
 [Content Brief]

[2]. Huang H, et al. Potent inhibitory effect of δ-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo. J Agric Food Chem. 2014 Nov 5;62(44):10752-8.
 [Content Brief]

[3]. Bak MJ, et al. Inhibitory Effects of γ- and δ-Tocopherols on Estrogen-Stimulated Breast Cancer In Vitro and In Vivo. Cancer Prev Res (Phila). 2017 Mar;10(3):188-197.
 [Content Brief]