For research use only. Not for therapeutic Use.
Deltasonamide 1 is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM. Deltasonamide 1 can be used for the research of tumors[1].
Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM[1].
Deltasonamide 1 binds to PDE6δ with up to 7 hydrogen bonds, resulting in picomolar affinity[1].
Deltasonamide 1 strongly reduces proliferation[1].
| Catalog Number | I015353 |
| CAS Number | 2088485-33-8 |
| Synonyms | 4-N-[(4-chlorophenyl)methyl]-4-N-cyclopentyl-1-N-[[2-(methylamino)pyrimidin-4-yl]methyl]-1-N-(piperidin-4-ylmethyl)benzene-1,4-disulfonamide |
| Molecular Formula | C30H39ClN6O4S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C30H39ClN6O4S2/c1-32-30-34-19-16-26(35-30)22-36(20-24-14-17-33-18-15-24)42(38,39)28-10-12-29(13-11-28)43(40,41)37(27-4-2-3-5-27)21-23-6-8-25(31)9-7-23/h6-13,16,19,24,27,33H,2-5,14-15,17-18,20-22H2,1H3,(H,32,34,35) |
| InChIKey | FWBBCSKXUXMTJY-UHFFFAOYSA-N |
| SMILES | CNC1=NC=CC(=N1)CN(CC2CCNCC2)S(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)N(CC4=CC=C(C=C4)Cl)C5CCCC5 |
| Reference | [1]. Pablo Martín-Gago, et al. A PDE6δ-KRas Inhibitor Chemotype With Up to Seven H-Bonds and Picomolar Affinity That Prevents Efficient Inhibitor Release by Arl2. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428. |
