Deltazinone

• CAT Number: I025869
• CAS Number: 894554-89-3
• Molecular Formula: C27H31N5O2
• Molecular Weight: 457.58
• Purity: 98%
• Synonyms: Deltazinone
• Target: Phosphodiesterase (PDE)
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)-N-(2-phenylpropyl)butanamide
• InChI: InChI=1S/C27H31N5O2/c1-18-12-14-23(15-13-18)32-21(4)25-20(3)29-31(27(34)26(25)30-32)16-8-11-24(33)28-17-19(2)22-9-6-5-7-10-22/h5-7,9-10,12-15,19H,8,11,16-17H2,1-4H3,(H,28,33)
• InChIKey: HZNKNJCWLQLQMJ-UHFFFAOYSA-N
• SMILES: O=C(NCC(C1=CC=CC=C1)C)CCCN2N=C(C)C3=C(C)N(C4=CC=C(C)C=C4)N=C3C2=O

Deltazinone(CAT: I025869) is a highly potent and selective inhibitor of phosphodiesterase delta (PDEδ), a protein critical for the proper localization and function of oncogenic RAS proteins. By disrupting the interaction between PDEδ and RAS, Deltazinone impairs RAS-driven signaling pathways essential for cancer cell proliferation and survival. Compared to the earlier PDEδ inhibitor Deltarasin, Deltazinone exhibits reduced nonspecific cytotoxicity and closely mimics the phenotypic effects of PDEδ knockdown, particularly in human pancreatic cancer cell lines. This specificity positions Deltazinone as a promising compound in Oncology research, especially for developing targeted therapies against RAS-driven cancers.