For research use only. Not for therapeutic Use.
Demecarium is a parasympathomimetic that acts as an acetylcholinesterase inhibitor. It is one of several topical (applied directly to the affected area) medications used to reduce elevated intraocular pressure (IOP) associated with primary glaucoma in cats, dogs, and other animals. a cholinesterase inhibitor with sustained activity. It acts mainly on true (erythrocyte) cholinesterase. Application of HUMORSOL (demecarium) to the eye produces intense miosis and ciliary muscle contraction due to inhibition of cholinesterase, allowing acetylcholine to accumulate at sites of cholinergic transmission. These effects are accompanied by increased capillary permeability of the ciliary body and iris, increased permeability of the blood-aqueous barrier, and vasodilation. Myopia may be induced or, if present, may be augmented by the increased refractive power of the lens that results from the accommodative effect of the drug. HUMORSOL (demecarium) indirectly produces some of the muscarinic and nicotinic effects of acetylcholine as quantities of the latter accumulate.
Catalog Number | R016070 |
CAS Number | 56-94-0 |
Synonyms | 3,3’-[1,10-decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethylbenzenaminium Bromide; (m-Hydroxyphenyl)trimethylammonium Bromide Decamethylenebis[methylcarbamate];(m-hydroxyphenyl)trimethylammonium Bromide Decamethylenebis[methylcarbamate]; 3, |
Molecular Formula | C32H52Br2N4O4 |
Purity | ≥95% |
Target | Cholinesterase (ChE) |
Storage | -20°C |
IUPAC Name | trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium;dibromide |
InChI | InChI=1S/C32H52N4O4.2BrH/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8;;/h17-22,25-26H,9-16,23-24H2,1-8H3;2*1H/q+2;;/p-2 |
InChIKey | YHKBUDZECQDYBR-UHFFFAOYSA-L |
SMILES | CN(CCCCCCCCCCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C)C(=O)OC2=CC=CC(=C2)[N+](C)(C)C.[Br-].[Br-] |
Reference | </br>1:Outcomes of nonsurgical management and efficacy of demecarium bromide treatment for primary lens instability in dogs: 34 cases (1990-2004). Binder DR, Herring IP, Gerhard T.J Am Vet Med Assoc. 2007 Jul 1;231(1):89-93. PMID: 17605669 </br>2:The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. Ward DA, Abney K, Oliver JW.Vet Ophthalmol. 2003 Mar;6(1):23-5. PMID: 12641839 </br>3:Effect of topically applied 2% pilocarpine and 0.25% demecarium bromide on blood-aqueous barrier permeability in dogs. Krohne SG.Am J Vet Res. 1994 Dec;55(12):1729-33. PMID: 7887518 </br>4:Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Gum GG, Gelatt KN, Gelatt JK, Jones R.Am J Vet Res. 1993 Feb;54(2):287-93. PMID: 8430939 </br>5:Determination of demecarium bromide and related compounds by high-performance liquid chromatography. Cohn LJ, Greely VJ, Tibbetts DL.J Chromatogr. 1985 Mar 15;321(2):401-5. PMID: 4039333 </br>6:[CLINICAL OBSERVATIONS ON THE USE OF DEMECARIUM BROMIDE IN GLAUCOMA. PHARMACOLOGIC PROPERTIES OF DEMECARIUM AND PHYSOSTIGMINE IN EXPERIMENTS]. GBURKOWA A, POJDA SM.Klin Oczna. 1965;35:207-12. Polish. No abstract available. PMID: 14306815 </br>7:INHIBITION OF MONAMINE OXIDASE BY AN ANTICHOLINESTERASE (DEMECARIUM BROMIDE). PANT MC, PARMAR SS, BHARGAVA KP.Can J Biochem. 1964 Jul;42:1114-7. No abstract available. PMID: 14209399 </br>8:ROLE OF THE POLYMETHYLENE CHAIN IN DERIVATIVES OF DEMECARIUM BROMIDE ON THE INHIBITION OF MONOAMINE OXIDASE. PANT MC, PARMAR SS, BHARGAVA KP.J Pharm Pharmacol. 1964 Jul;16:503-4. No abstract available. PMID: 14207098 </br>9:Demecarium bromide: analysis of its action in selected group of glaucomas. DEUTSCH AR, ROWLETT WM.J Tn State Med Assoc. 1963 Jan;56:5-9. No abstract available. PMID: 14027379 </br>10:Clinical experiences with demecarium bromide (BC-48) in the treatment of glaucoma. TERNER IS, LINN JG Jr, GOLDSTROHM R.Am J Ophthalmol. 1961 Oct;52:553-60. No abstract available. PMID: 13920329 |