Demecolcine-d3

• CAT Number: R003608
• CAS Number: 1217668-72-8
• Molecular Formula: C21H25NO5
• Molecular Weight: 374.45
• Purity: ≥95%
• Synonyms: (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one-d3; Deacetylmethylcolchicine-d3; Colchamin-d3; NSC 3096-d3; Omain-d3; Omaine-d3; Reichstein’s F-d3;?N-Desacetyl-N-methylcolchicine-d3; Colcemid-d3
• Storage: Store at RT
• IUPAC Name: (7S)-1,2,3,10-tetramethoxy-7-(trideuteriomethylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
• InChI: InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1/i1D3
• InChIKey: NNJPGOLRFBJNIW-VSLDJYOXSA-N
• SMILES: [2H]C([2H])([2H])N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

Demecolcine-d3（Cat No.:R003608） is a deuterated form of demecolcine, a compound derived from colchicine, primarily used in cell biology research to inhibit mitosis by depolymerizing microtubules. The introduction of three deuterium atoms in demecolcine-d3 enhances its stability and reliability in experimental conditions, making it particularly useful for detailed cellular and molecular studies. This isotopic labeling allows for precise tracking and quantification in pharmacokinetic studies, crucial for understanding the drug’s behavior within biological systems. Demecolcine-d3 is essential for researchers investigating cell division mechanisms and developing new therapeutic strategies for cancer treatment.