For research use only. Not for therapeutic Use.
<br />Antineoplastic alkaloid<!–C<SUB>21</SUB>H<SUB>25</SUB>NO<SUB>5</SUB>–>isolated from <I>Colchicum autumnale</I> (Liliaceae Fam.)</br><p>An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. It stimulates the intrinsic GTPase activity of tubulin, induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal.</p></br>
| Catalog Number | R002400 |
| CAS Number | 477-30-5 |
| Synonyms | (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one; Deacetylmethylcolchicine; Colchamin; NSC 3096; Omain; Omaine; Reichstein’s F;?N-Desacetyl-N-methylcolchicine; Colcemid; |
| Molecular Formula | C21H25NO5 |
| Purity | ≥95% |
| Target | Cytoskeleton |
| Storage | -20°C |
| IUPAC Name | (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one |
| InChI | InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1 |
| InChIKey | NNJPGOLRFBJNIW-HNNXBMFYSA-N |
| SMILES | CNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
| Reference | – Kh. N. Aripov, /The chemistry of plant substances in Uzbekistan/, Chemistry of Natural Compounds (1995), Volume 31, Issue 1, pp 2-15<br /><br /><br /><br /> |
