Demethylcantharidate disodium

• CAT Number: I044968
• CAS Number: 129-67-9
• Molecular Formula: C8H8Na2O5
• Molecular Weight: 230.13
• Purity: ≥95%
• Synonyms: disodium;7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate
• InChI: InChI=1S/C8H10O5.2Na/c9-7(10)5-3-1-2-4(13-3)6(5)8(11)12;;/h3-6H,1-2H2,(H,9,10)(H,11,12);;/q;2*+1/p-2
• InChIKey: XRHVZWWRFMCBAZ-UHFFFAOYSA-L
• SMILES: C1CC2C(C(C1O2)C(=O)[O-])C(=O)[O-].[Na+].[Na+]

Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer[1].
Demethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours)? disodium inhibits HCC cell proliferation[1].?
Demethylcantharidate (0, 9, 18 or 36 μM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2[1].
Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo[1].

Reference

[1]. Ye M, et al. Sodium demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress. Am J Transl Res. 2019;11(5):3150-3158. Published 2019 May 15.
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