Denotivir

• CAT Number: I025887
• CAS Number: 51287-57-1
• Molecular Formula: C18H14ClN3O2S
• Molecular Weight: 371.84
• Purity: 98%
• Synonyms: Denotivir; T15; T 15; T-15
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4-Isothiazolecarboxamide, 5-(benzoylamino)-N-(p-chlorophenyl)-3-methyl-
• InChI: InChI=1S/C18H14ClN3O2S/c1-11-15(17(24)20-14-9-7-13(19)8-10-14)18(25-22-11)21-16(23)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,24)(H,21,23)
• InChIKey: ZPBLNADJHWHOEP-UHFFFAOYSA-N
• SMILES: O=C(C1=C(NC(C2=CC=CC=C2)=O)SN=C1C)NC3=CC=C(Cl)C=C3

Denotivir is an isothiazole derivative of 5-amino-3-methylisothiazolocarboxylic acid I with antiviral activity against human herpes simplex viruse types 1 and 2, and varicella zoster virus.

Reference

1: Machoń Z, Wieczorek Z, Zimecki M. Immunotropic activity of vratizolin (ITCL, Denotivir). Pol J Pharmacol. 2001 Jul-Aug;53(4):377-83. PMID: 11990084.
2: Godlewska M, Zgoda MM. Release of denotivir from the dispersed systems. Part I. Properties of hydrogel vehiculum and availability of active substance from intravaginal form of drug. Acta Pol Pharm. 1996 Nov-Dec;53(6):403-10. PMID: 9415215.
3: Regiec A, Machoń Z, Miedzybrodzki R, Szymaniec S. New isothiazole derivatives: synthesis, reactivity, physicochemical properties and pharmacological activity. Arch Pharm (Weinheim). 2006 Jul;339(7):401-13. doi: 10.1002/ardp.200500040. PMID: 16838283.
4: Daidone G, Plescia F, Maggio B, Raffa D, Cutuli VM, Mangano NG, Caruso A. Phenylamides of 1-phenyl (or methyl)-5-benzamidopyrazole-4-carboxylic acid as vratizolin analogs with analgesic and antiinflammatory activities. Arch Pharm (Weinheim). 2001 May;334(5):153-6. doi: 10.1002/1521-4184(200105)334:5<153::aid- ardp153>3.0.co;2-7. PMID: 11413820.