Deoxy-Thymidine triphosphate

• CAT Number: I025905
• CAS Number: 365-08-2
• Molecular Formula: C10H17N2O14P3
• Molecular Weight: 482.17
• Purity: ≥95%
• Synonyms: Deoxy-TTP; dTTP; Deoxy-Thymidine triphosphate
• Target: Metabolic Enzyme/Protease
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
• IUPAC Name: [Hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
• InChI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1
• InChIKey: NHVNXKFIZYSCEB-XLPZGREQSA-N
• SMILES: O=P(OP(O)(O)=O)(OP(OC[C@H]1O[C@@H](N(C(N2)=O)C=C(C)C2=O)C[C@@H]1O)(O)=O)O

Deoxy-Thymidine triphosphate (Cat.No:I025905), also known as dTTP, is a ligand which corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator upon binding to a remote site thermodynamically.

Reference

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2: Sirivolu VR, Vernekar SK, Ilina T, Myshakina NS, Parniak MA, Wang Z. Clicking 3′-azidothymidine into novel potent inhibitors of human immunodeficiency virus. J Med Chem. 2013 Nov 14;56(21):8765-80. doi: 10.1021/jm401232v. Epub 2013 Oct 28. PubMed PMID: 24102161; PubMed Central PMCID: PMC4027054.
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