For research use only. Not for therapeutic Use.
Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breast cancer cells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound[1].
Deoxylimonin (0-90 μg/mL, 48 h) treatment shows anti-proliferation activities to breast cancer cells[2].
Deoxylimonin (oral administration; 70 mg/kg; once) treatment shows antinociception effects in vivo[1].
| Catalog Number | I044893 |
| CAS Number | 989-23-1 |
| Synonyms | (1R,2R,7S,10R,13R,18R,19R)-18-(furan-3-yl)-9,9,13,19-tetramethyl-4,8,17-trioxapentacyclo[11.8.0.02,7.02,10.014,19]henicos-14-ene-5,12,16-trione |
| Molecular Formula | C26H30O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H30O7/c1-23(2)16-9-18(27)25(4)15(26(16)13-31-20(28)11-19(26)33-23)5-7-24(3)17(25)10-21(29)32-22(24)14-6-8-30-12-14/h6,8,10,12,15-16,19,22H,5,7,9,11,13H2,1-4H3/t15-,16-,19-,22-,24+,25+,26+/m0/s1 |
| InChIKey | QUTATOGBENCRSS-JWLOEITESA-N |
| SMILES | CC1(C2CC(=O)C3(C(C24COC(=O)CC4O1)CCC5(C3=CC(=O)OC5C6=COC=C6)C)C)C |
| Reference | [1]. Shaochi Wang, et al. Discovery of deoxylimonin δ-lactam derivative with favorable anti-inflammation and antinociception efficacy from chemical modified limonin/deoxylimonin analogs. Bioorg Chem. 2020 Jul;100:103886. [2]. N. Guthri, et al. Inhibition of Human Breast Cancer Cells by Citrus Limonoids. ACS Symposium SeriesVol. 758, July 30, 2000. |
